Lompoc is located on scenic California State Highway 1 & 246, 55 miles north of Santa Barbara, & 155 miles north of Los Angeles and 270 miles south of San Francisco. Vandenberg Air Force Base is 10 miles north of the city.

The Lompoc Valley is part of the Central California region. Rolling Hills surround the Valley on the north, south and east. The level Valley is open at its western end to the Pacific Coast Shoreline. The Pacific Ocean is only 9 miles from downtown Lompoc. The Santa Ynez River (dry most of the year) runs east to west through the Valley while Burton Mesa, a chaparral forest with sandy soil, lies to the north. The hills to the south are mined for diatomaceous (fossil) earth.

Elevation - 88 Feet above mean sea level.

Lompoc has a mild climate. A northwest breeze is common (average hourly wind speed: 6.1 m.p.h.). There is moderate rainfall, summerfog and no snow.